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DESIGN OF A DYNAMIC FOCUSING MICROSCOPE OBJECTIVE FOR OCT IMAGING
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TitleDESIGN OF A DYNAMIC FOCUSING MICROSCOPE OBJECTIVE FOR OCT IMAGING
AuthorMurali, Supraja
KeywordsOptical coherence tomography
microscope objective
dynamic focusing
AbstractOptical Coherence Tomography (OCT) is a novel optical imaging technique that has assumed significant importance in bio-medical imaging in the last two decades because it is non-invasive and provides accurate, high resolution images of three dimensional cross-sections of body tissue, exceeding the capabilities of the current predominant imaging technique –ultrasound. In this thesis, high resolution OCT is investigated for in vivo detection of abnormal skin pathology for the early diagnosis of cancer. The technology presented is based on a dynamic focusing microscopic imaging probe conceived for skin imaging and the detection of abnormalities in the epithelium. A novel method for dynamic focusing in the biological sample using liquid crystal (LC) lens technology to obtain three dimensional images with invariant resolution throughout the cross-section and depth of the sample is presented and discussed. Two different skin probe configurations that incorporate dynamic focusing with LC lenses, one involving a reflective microscope objective sub-system, and the other involving an all-refractive immersion microscope objective sub-system are investigated. In order to ensure high resolution imaging, a low coherence broadband source, namely a femtosecond mode-locked Ti: sapphire laser centered at a wavelength of approximately 800nm is used to illuminate the sample. An in-depth description and analysis of the optical design and predicted performance of the two microscope objectives designed for dynamic three dimensional imaging at 5ìm resolution for the chosen broadband spectrum is presented.
AdviserRolland, Jannick
PublisherUniversity of Central Florida
DegreeM.S.
Degree GrantorOptics and Photonics
Degree ProgramOptics
Graduation Date2005-12-01
TypeMaster's thesis
Access LevelPublic - Allow Worldwide Access
Release Date2007-01-11
RepositoryUniversity Archives
Repository CollectionElectronic Theses and Dissertations
IdentifierCFE0000869
Access Linkhttp://purl.fcla.edu/fcla/etd/CFE0000869

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