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EFFECTIVENESS OF PROBIOTICS IN PREVENTING ANTIBIOTIC ASSOCIATED DIARRHEA AND CLOSTRIDIUM DIFFICILE IN LONG TERM CARE
Access this item.
Title
EFFECTIVENESS
OF
PROBIOTICS
IN
PREVENTING
ANTIBIOTIC
ASSOCIATED
DIARRHEA
AND
CLOSTRIDIUM
DIFFICILE
IN
LONG
TERM
CARE
Author
Edwards-Marshall, Marva
Keywords
Probiotics
long term care
antibiotic associated diarrhea
clostridium difficile
geriatrics.
Abstract
Purpose:
Antibiotic
associated
diarrhea
(AAD)
and
clostridium-difficile
diarrhea
(CDAD)
are the
most
common
forms
of
infectious
diarrhea
in
long
term
care
facilities.
The
purpose
of this
study
is
to
determine
the
effectiveness
of
probiotics
in
preventing
AAD
and
CDAD
in the
long
term
care
geriatric
population
, and to
identify
interventions
which
can
be
used
to
improve
clinical
practice.
Methods:
This was a
retrospective
cohort
study.
The
study
population
consisted
of
residents
of a
LTC
facility
who
were
sixty-five
years
of
age
and
older
who
were
administered
antibiotic
therapies
with or
without
co-administration
of
probiotics.
A
data
collection
instrument
which
was
created
for this
study
was
piloted
prior
to its
use
in the
study.
Chi-square
test
of
independence
and
CochranÂ
s
Q
were the
proposed
statistical
analysis
procedures
used
to
determine
relationships
between
variables.
Results:
Eighty-three
residents
received
antibiotics.
In the
forty-four
residents
who
were
administered
probiotic
with
antibiotic
,
five
cases
of
diarrhea
were
reported.
In the
thirty-nine
residents
who
received
antibiotics
without
probiotics
,
two
cases
of
diarrhea
were
reported.
Analysis
with
chi-square
test
of
independence
comparing
the
relationship
between
antibiotic
administration
with and
without
probiotic
and
AAD
prevention
, was
(X²(1)
=1.041
,
p=0.308).
No
cases
of
CDAD
were
found
in the
group
who
received
antibiotic
(s)
and a
probiotic.
One
case
of
CDAD
was
found
in the
group
which
received
no
probiotic
with the
antibiotic.
Analysis
with
chi-square
test
of
independence
comparing
the
relationship
between
antibiotic
administration
with or
without
probiotic
and
CDAD
prevention
was
(X²(1)
=1.142
,
p=0.285).
Discussion/Implication:
The
results
of this
study
showed
no
statistically
significant
evidence
to
support
the
effectiveness
of
probiotic
use
in the
prevention
of
AAD
or
CDAD
in this
population.
The
incidence
of
AAD
was
higher
in the
group
who
received
a
probiotic
at the
time
of
antibiotic
administration.
Adviser
Wink, Diane
Publisher
University
of
Central
Florida
Degree
D.N.P.
Degree Discipline
School of Nursing
Degree Grantor
Health and Public Affairs
Degree Program
Nursing Practice DNP
Graduation Date
2010-01-01
Type
Doctoral dissertation
Access Level
Public - Allow Worldwide Access
Release Date
2010-08-18
Repository
University Archives
Repository Collection
Electronic Theses and Dissertations
Identifier
CFE0003281
Access Link
http://purl.fcla.edu/fcla/etd/CFE0003281
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