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RAMAN SPECTROSCOPIC STUDY OF SINGLE RED BLOOD CELLS INFECTED BY THE MALARIA PARASITE PLASMODIUM FALCIPARUM
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TitleRAMAN SPECTROSCOPIC STUDY OF SINGLE RED BLOOD CELLS INFECTED BY THE MALARIA PARASITE PLASMODIUM FALCIPARUM
AuthorCarter, William
KeywordsRaman
Malaria
Plasmodium
Falciparum
AbstractRaman micro-spectroscopy provides a non-destructive probe with potential applications as a diagnostic tool for cellular disorders. This study presents micro-Raman spectra of live erythrocytes infected with a malaria parasite and investigates the potential of this probe to monitor molecular changes which occur during differentiation of the parasite inside the cell. At an excitation wavelength of 633 nm the spectral bands are dominated by hemoglobin vibrations yielding information the on structure and spin state of the heme moiety. It also demonstrates the novel use of silica capillaries as a viable method for studying the erythrocytes in an environment that is much closer to their native state, thus opening the possibility of maintaining the cell in vivo for long periods to study the dynamics of the parasite's growth.
AdviserSchulte, Alfons
PublisherUniversity of Central Florida
DegreeM.S.
Degree DisciplineDepartment of Physics
Degree GrantorSciences
Degree ProgramPhysics MS
Graduation Date2007-01-01
TypeMaster's thesis
Access LevelPublic - Allow Worldwide Access
Release Date2007-09-18
RepositoryUniversity Archives
Repository CollectionElectronic Theses and Dissertations
IdentifierCFE0001780
Access Linkhttp://purl.fcla.edu/fcla/etd/CFE0001780

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