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GENETIC ANALYSIS OF RHOA SIGNALING DURING EPITHELIAL MORPHOGENESIS IN DROSOPHILA
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TitleGENETIC ANALYSIS OF RHOA SIGNALING DURING EPITHELIAL MORPHOGENESIS IN DROSOPHILA
AuthorLeppert, Amanda Fitch
KeywordsArts and Sciences -- Dissertations, Academic
Dissertations, Academic -- Arts and Sciences
Actin cytoskeleton
Contractile belt
Epithelial morphogenesis
Leg imaginal disc
RhoA
Stubble stubbloid
AbstractEpithelial morphogenesis is contingent upon cell shape changes. Cell shape changes are the driving force for the metamorphosis of the adult Drosophila leg from the leg imaginal disc precursor. Genetic analysis has identified several Drosophila genes involved in regulating cell shape changes during leg disc morphogenesis. These include members of the RhoA signaling pathway and the product of the Stubble-stubbloid (Sb-sbd) locus, a transmembrane serine protease. Mutations in the Sb-sbd gene interact genetically with the members of the RhoA signaling pathway, however the nature of the relationship between Sb-sbd serine protease activity and RhoA signaling is not understood. To identify additional components of the RhoA signaling pathway that may help us to understand the role of the Sb-sbd protease in RhoA signaling the Drosophila genome was systematically scanned for genes that interact with Sb-sbd and RhoA mutations using deletions/deficiencies of specified regions of each chromosome. A total of 201 deficiencies uncovering approximately 84.9-91% of the euchromatic genome and spanning the X, second, and third chromosoms were tested. Of the 201 deficiencies tested, five putative interacting genetic regions and one gene within these deficiencies were identified. The candidate gene Eip78C encodes a nuclear steroid hormone receptor previously identified as having an important role in metamorphosis.
Adviservon Kalm, Laurence
PublisherUniversity of Central Florida
DegreeM.S.
Degree DisciplineDepartment of Biology
Degree GrantorArts and Sciences
Degree ProgramBiology
Graduation Date2004-05-01
TypeMaster's thesis
Access LevelPublic - Allow Worldwide Access
Release Date2004-05-01
RepositoryUniversity Archives
Repository CollectionElectronic Theses and Dissertations
IdentifierCFE0000046
Access Linkhttp://purl.fcla.edu/fcla/etd/CFE0000046

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